Polynucleotides for Skin
Salmon-DNA injectable that improves skin quality from within. Particularly effective on the under-eye and neck.
- Procedure
- 45 minutes
- Anaesthesia
- Numbing cream
- Recovery
- Mild swelling, 24 hours
- Results
- Visible at 4–6 weeks · 6 months
- From
- From £400
- Practitioner
- Doctor
- Sessions
- Course of 2–3 at three-week intervals
What are polynucleotides?
Polynucleotides are short fragments of DNA derived from purified salmon trout — molecules that, once introduced into the skin, prompt fibroblast activity, support tissue hydration, and modulate inflammation. They have been used in regenerative medicine in Italy and Korea for over a decade and are now widely available in the UK, with strong peer-reviewed evidence for use on the under-eye, jaw, neck and décolleté.
We use polynucleotides as a regenerative treatment — they are not a filler. They will not add volume or change the shape of a feature. What they do is improve the tissue itself: the skin becomes denser, better hydrated, and more reflective.
How it works
A small volume of polynucleotide gel is delivered via fine needle into the layer between skin and underlying tissue. The DNA fragments break down over the following weeks, releasing nucleotides that fibroblasts use as raw material to produce new collagen, elastin and hyaluronic acid. Inflammation is reduced. Microcirculation improves. The skin looks visibly fresher within four to six weeks, with peak result at the eight-to-ten-week mark.
Who it's for
Polynucleotides are particularly good on the under-eye area, where filler is risky and resurfacing is harsh. They also work well on the neck, jaw and décolleté — areas where the skin is thin, sun-damaged, and difficult to improve with other modalities.
The Lumara protocol
We typically recommend a course of two to three sessions at three-week intervals. The first session establishes the regenerative response; subsequent sessions consolidate it. Where the area being treated is small (under-eye only), a single session can be enough. We will tell you so at consultation.
Aftercare
Mild swelling at the injection points for 24 hours; occasional small bruising for up to 5 days. Avoid alcohol, exercise and saunas for 48 hours. Results build slowly — please don't judge the outcome at week one.
Frequently asked
Polynucleotides for Skin, in plain English.
Is this safe if I have a fish allergy?
The polynucleotide is derived from purified salmon DNA, but the purification process removes the protein elements that trigger fish allergies. We will discuss this in detail at consultation; clients with severe fish allergy will be assessed individually.
How is this different from filler?
Filler adds volume and changes shape. Polynucleotides do neither — they improve the quality of the skin tissue itself. They can be used in places where filler is not safe (such as under the eye, where filler can migrate and discolour). Many clients use both, on different areas.
Can polynucleotides help with dark circles?
If your dark circles are caused by thin, crepey under-eye skin, polynucleotides can meaningfully improve them by densifying and brightening the tissue. If they are caused by underlying pigmentation or by a hollow tear trough, polynucleotides will not address that — and we will say so honestly.
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Begin with a conversation
Book a consultation.
Every Polynucleotides for Skin client begins with a discovery consultation, in person at our Marylebone clinic or by video. We map the concern, explain the protocol, and tell you honestly whether we'd recommend it.